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Agilent 1260 High Performance Liquid Chromatograph (HPLC) with diode array detector 

A pressure range of up to 600 bar with a flow rate up to 
5 mL/min allows the use of almost any column – conventional, sub-2 µm-particle or superficially porous columns. A UV, fluorescence or ELSD detector provides the data rate required for high resolution separations or fast analyses. 

Molecular Devices Gene Pix 4100A  

Genomics

• SNP genotyping arrays
• Arrayed comparative genomic hybridization (aCGH) arrays

Transcriptomics

• Gene expression arrays
• RNA interference (RNAi) arrays
• MicroRNA (miRNA) arrays

Proteomics

• Protein arrays
• Peptide arrays
• Antibody arrays
• ELISA arrays
• Reverse Phase Arrays

Epigenomics

• DNA methylation arrays

• Chromatin immunoprecipitation (ChIP) arrays

Novel Applications

• Tissue arrays
• Quantum Dots
• Carbohydrate Arrays
• Chemical Compound Arrays

Spectramax M5 microplate reader Spectrophotometer

The optical systems use two scanning monochromators so the user can determine optimal excitation and emission settings, resulting in assay performance similar to
that of dedicated single-mode readers.

Source: Molecular Devices: SpectraMax M Series Multi-Mode Microplate Readers Manual and Molecular Devices GenePix 4100A Microarray Scanner website

Perkin Elmer Tri Carb 3110TR Liquid Scintillation Analyzer

The Tri-Carb® 3110TR is a computer-controlled benchtop liquid scintillation analyzer for detecting small amounts of alpha, beta and gamma radioactivity.

 

Source: PerkinElmer Tri-Carb 3110TR Low Activity Liquid Scintillation Analyzer Spec Sheet

 

Applied Biosystems Hitachi 3500 Genetic Analyzer

The Applied Biosystems 3500/3500xL Genetic Analyzers are fluorescence based DNA analysis instrument using capillary electrophoresis technology with 8- or 24-capillaries.

Source: Applied Biosystems 3500/3500XL Genetic Analyzer User Guide

Instrumentation used in the 2019 1st Place NAMS symposium Analysis of Soil Bacteria for the Production of Antibiotics

Poster

Beckman CEQ8000XL Automated DNA Sequencer

This system is fully automated and capable of determining the base sequence and fragment length of DNA samples that have been prepared with dye-labeled reagents. Four-color, dye-labeled terminator chemistry kits are used to process samples for base sequence analysis. Generation of samples for fragment length analysis is performed using dye-labeled primers.

Source: CEQ^TM 8000 Genetic Analysis System User's Guide

The Biomek® 3000 Laboratory Automation Workstation

The Biomek® 3000 Laboratory Automation Workstation is a multi-axis liquid handling instrument designed for benchtop use and to fit in a laminar flow or fume hood for sterile or hazardous operations. The open architecture design, along with the extensible operating software, provides a foundation for integrating current and future specific-use components.

The Biomek 3000 workstation is a single head instrument with a series of interchangeable tools. Different tools provide options for performing a variety of functions, including liquid transfer and plate washing operations and moving labware around the deck. The modular design of the Biomek 3000 workstation allows expansion of the instrument capabilities to include additional operations such as filtration, plate shaking, photometric microplate measurement, and high-capacity operation.

A variety of labware and hardware adapt the deck of the Biomek 3000 workstation to accomplish multiple tasks, ranging from performing simple labware positioning and liquid transfers to completing complex assays that typically require additional devices in the laboratory.

Source: Beckman Coutler Biomek® 3000 Laboratory Automation Workstation User's Manual

Coy Anaerobic Chamber

Used for anerobic microbiology research, these units are also critical to many other research areas such as protein purification, clinical microbiology, biochemistry, cell culture, human microbiome studies, biofuels and more. 

Source: Coylab.com/products/anareobic-chambers

 

 

Leica Microsystems Microscope

Precise 5W LED illumination ideal for cell and tissue culture, microamplification and live cell examinations.

 

Source: Leica Microsystems

 

Leica TCS SPE Confocal Microscope

Providing all of the features needed for routine confocal techniques, it offers excellent quality imaging. 

• The common Leica LAS X interface facilitates direct operation.
• Provides true spectral detection suitable for lambda scan.
• Is intuitively controlled and even users who are new to confocal microscopy, will get publication-quality results immediately.

High Fideliity Specral Imaging

The prism-based spectral detection – unique to all Leica confocal microscopes – and a highly dynamic photomultiplier offer extraordinary signal efficiency for gapless detection of even weak signals. A variety of robust solid-state lasers allow the use of a broad range of common dyes.

Source: Leica Microsystems

 

Molecular Devices Gene Pix 4100A  

Genomics

Transcriptomics

Proteomics

Epigenomics

Novel Applications

Source: Moleculardevices.com

Spectramax M5 microplate reader Spectrophotometer

The optical systems use two scanning monochromators so the user can determine optimal excitation and emission settings, resulting in assay performance similar to
that of dedicated single-mode readers.

Source: Spectramax M Series Multi-Mode Microplate Readers User Manual

Seal Analytical AA3 Dissolved Nutrient Analyzer

Based on air Segmented Flow Analysis techniques (also known as Continuous Flow Analysis), the SEAL AutoAnalyzer 3 fully automates repetitive and complex sample analysis steps, from start-up to shutdown. The SEAL AA3 HR chemistry analyzer can also perform solvent extraction, distillation, gas diffusion, on-line filtration and in-line UV digestion in a continuously flowing stream. SEAL AA3 HR chemistry analyzers are fully supported with a library of over 700 documented applications including USEPA, ISO and ASTM standard methods.

Source: SealAnalytical.com

XROMM Analyzer

X-Ray Reconstruction of Moving Morphology (XROMM) is a 3D imaging technology for visualizing rapid skeletal movement in vivo. 

XROMM combines 3D models of bone morphology with movement data from biplanar x-ray video to create highly accurate (±0.1 mm) re-animations of the 3D bones moving in 3D space. 

Rapid bone motion, such as during bird flight, frog jumping, and human running, can be visualized and quantified with XROMM.

Source: Xromm.org

Agilent 1260 High Performance Liquid Chromatograph (HPLC) with diode array detector 

A pressure range of up to 600 bar with a flow rate up to 
5 mL/min allows the use of almost any column – conventional, sub-2 µm-particle or superficially porous columns. A UV, fluorescence or ELSD detector provides the data rate required for high resolution separations or fast analyses. 

Source: labwrench.com

Agilent 7890B Gas Chromatographs (GC) with autosamplers and a variety of detectors: ECD, TCD, FID, MSD

Gas chromatography, coupled with static
headspace sampling, is an easy-to-use,
high-throughput tool for determining
residual solvent impurities in pharmaceutical
products. Sample preparation is simple, and
the method is easily validated. In addition,
headspace sampling allows you to avoid
matrix injections that can cause column
degradation and coelution.

Source: Agilent 7890B Gas Chromatograph brochure 

Instrumentation used in the 2019 1st Place NAMS symposium Analysis of Soil Bacteria for the Production of Antibiotics

Poster

 

Agilent Cary Eclipse Fluorescence Spectrophotometer

The fibre optic capabilities extend the utility of the system for simplified measurement of solid samples outside the sample compartment or for the direct measurement of cold, hot, or potentially dangerous samples, down to very low volumes.

Food

• Additives and supplements. Quality
  Assurance testing and monitoring
• Authenticity and food origin
• Food packaging and processing
  including hydrocarbon contamination
  through processing

Environmental

• Preliminary Identification of hydrocarbon
  origin in oil spills using synchronous
  scanning
• Waste water tracing into environmental
  flows by using fluorescent markers
• Investigation of the source of organic
  matter pollution in river and sea water

Chemical and Materials Applications

• Determination of fluorescent properties
  of cleaning products
• Investigation of the fluorescent
  properties of optical components
• Analysis of surface contamination by
  fluorescent organic compounds in
  manufacturing processes
• Polarized (anisotropy) measurements
  for understanding the molecular
  environment during polymer research

Source: Agilent Cary Eclipse Fluorescence Spectrophotometer spec sheet

Agilent 240 FS AA Flame Atomic Absorption Spectrophotometer Hollow Cathode Lamps

Atomic absorption spectrophotometry analyzes the concentration of elements in a liquid sample based on energy absorbed from certain wavelengths of light (usually 190 to 900 nm). Atomic absorption spectrophotometers typically include a flame burner to atomize the sample (most commonly a hollow cathode lamp), a monochromator, and a photon detector. Equipped with a turret or fixed lamp socket that can hold multiple lamps (up to eight) to reduce downtime between samples or allow for sequential analysis.

Typical sensitivity for an atomic absorption spectrometer using a flame burner is in the parts per million range. For trace analysis, a graphite furnace can be used in place of a flame burner to increase the sensitivity by several orders of magnitude (in the parts per billion range). Atomic absorption spectrophotometers are used in many industries including environmental testing, metal analysis, semiconductor manufacturing, petroleum and chemical production, and in pharmaceuticals, for example.

Source: labcompare.com

Bruker Advance 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

Analytical nuclear magnetic resonance (NMR) solutions and instruments for life science and material research applications.

Nuclear magnetic resonance spectroscopy is used to study the structure of molecules, the interaction of various molecules, the kinetics or dynamics of molecules and the composition of mixtures of biological or synthetic solutions or composites.

The size of the molecules analyzed can range from a small organic molecule or metabolite, to a mid-sized peptide or a natural product, all the way up to proteins of several tens of kDa in molecular weight.

NMR nuclear spectroscopy complements other structural and analytical techniques such as X-ray, crystallography and mass spectrometry. NMR’s advantage is the unique ability of a nuclear spectrometer to allow both the non-destructive and the quantitative study of molecules in solution and in solid state, as well as to enable the study of biological fluids.

Source: bruker.com

 

 

CEM MARS 6 Microwave system

Microwave is a technique used to dissolve solid sample matrices into an aqueous liquid. This is achieved by placing a sample in a concentrated acid matrix in a closed vessel and exposing it to microwave irradiation. Both the speed of thermal decomposition of the sample, and the solubility of metals are increased. Once these metals are in solution, they can be quantified through spectroscopic techniques. The MARS 6 acid digestion process routinely cuts the time of sample preparation by 50 – 75 % as compared to hot plates and hot block.

Source: CEM.com

 

Dionex 5000 Ion Chromatographs (IC)

Ideally suited for trace level determinations with high matrix concentrations, using a standard or microbore column in the first dimension to separate analytes from matrix, followed by a capillary separation in the second dimension. This method provides high sensitivity, enabling conductivity detection limits to rival those of mass spectrometry.

Source: ThermoFisher.com 

 

 

TA Instruments Q10 Differential Scanning Calorimeter (DSC)

The most common DSC application is the precise measurement of transition temperature.
Whether a melting temperature of a polymer
or the polymorphic transition of a pharmaceutical,
DSC provides the information quickly and easily on a minimum amount of sample. Important temperature measurements include:

• Melting Temperature
• Glass Transition Temperature
• Thermal Stability Temperature
• Oxidation Onset Temperature
• Cure Onset Temperature
• Crystallization Temperature
• Polymorphic Transition Temperature
• Liquid Crystal Temperature
• Protein Denaturation Temperature
• Solid-Solid Transition Temperature

Source: tainstruments.com/brochure

Teledyne Leeman Labs Hydra II Mercury Analyzer

It is a fully automated turnkey analyzer that measures mercury in solid and semi-solid sample matrices directly without any acid digestion (sample preparation). The system employs the technique of sample combustion (thermal decomposition), mercury concentration via gold amalgamation and detection by cold vapor atomic absorption.

Source: teledyneleemanlabs.com

 

Thermo Nicolet iS5 FTIR with ATR attachment

Infrared spectroscopy is the analytical technique for rapid identification of unknown materials (solids, liquids and gases) and product quality screening. 

Source: fishersci.com

 

Thermo Nicolet iS50 FTIR Spectrometer with ATR and multi-range beam splitter

The Nicolet iS50 analyzes complex mixtures and materials using its GC-IR or TGA-IR capabilities. The new OMNIC Mercury software automatically isolates and identifies compounds eluted from a GC column or evolved from a TGA. This functionality is especially useful in TGA, where several compounds can evolve at the same time. Such analyses provide insight into subtle formulation differences in plastics and rubbers, which can lead to not-so-subtle differences in product performance and quality.

Source: News-medical.net

 

Nicolet FT-IR Spectrometer

Uses infrared energy to excite the atoms of a material. The spectrum of the light absorbed and transmitted as the atoms vibrate provides a fingerprint of the structure of the molecules in the sample. This fingerprint can used to identify the chemical bonds present in the sample.

The Nicolet 6700 is currently equipped with a diamond crystal single bounce attenuated total reflectance (ATR) attachmen

Rigaku MiniFlex 600 X-ray Diffractometer (powder) with 6-sample changer

MiniFlex X-ray diffractometer (XRD) is a multipurpose analytical instrument that can determine: phase identification and quantification, percent (%) crystallinity, crystallite size and strain, lattice parameter refinement, Rietveld refinement, and molecular structure. It is widely used in research, especially in material science and chemistry, as well as in industry for research and quality control.

Source: Rigaku.com 

Rigaku XtaLAB mini X-ray Diffractometer (single crystal) (XRD)

The Rigaku XtaLAB, benchtop X-ray crystallography system, is a compact single crystal X-ray diffractometer designed to produce publication-quality 3D structures. Rapidly analyze new compounds as they are synthesized in the lab.

Source: Rigaku.com